2 papers
stat.ME2025
Determining vaccine responders in the presence of baseline immunity using single-cell assays and paired control samples
Zhe Chen, Siyu Heng, Asa Tapley +2
A key objective in vaccine studies is to evaluate vaccine-induced immunogenicity and determine whether participants have mounted a response to the vaccine. Cellular immune response…
stat.ME2025
Negative Control Outcome Adjustment in Early-Phase Randomized Trials: Estimating Vaccine Effects on Immune Responses in HIV Exposed Uninfected Infants
Ethan Ashby, Bo Zhang, Genevieve G Fouda +2
Adjustment for prognostic baseline variables can reduce bias due to covariate imbalance and increase efficiency in randomized trials. While the use of covariate adjustment in late-…