36 citations · 221 across the 27 of their papers we have counts for
29 papers
Spatiotemporally-resolved differential dynamic microscopy reveals strain-induced deformations in heterogeneous soft materials
Aysan Razzaghi, Mehrzad Sasanpour, Jasmine Ren +5
Understanding the microscopic behavior of materials in response to mechanical perturbations is a central challenge in soft matter, yet existing methods, which typically rely on mic…
Pinned Boundaries Delay Contraction and Shape Stress Relaxation in Active Gels
Aniket Marne, James Clarke, Aravind Rao +6
Cells dynamically generate, transmit, and dissipate stress. Central to these processes is the actomyosin cortex, an active contractile material that drives cellular mechanical beha…
Starch granules are instructive scaffolds for synergistic reinforcement and dissipation in hydrogel composites
Shirlaine Juliano, Jasmine Samaniego, Ian M Lillie +3
A fundamental challenge in soft material design is the competition between rigidity and dynamicity, as stiffening mechanisms typically suppress energy dissipation. Here, we demonst…
BARCODE: Biomaterial Activity Readouts to Categorize, Optimize, Design and Engineer for high throughput screening and characterization of dynamically restructuring soft materials
Qiaopeng Chen, Aditya Sriram, Ayan Das +8
Active, responsive, nonequilibrium materials, at the forefront of materials engineering, offer dynamical restructuring, mobility and other complex life-like properties. Yet, this e…
Active and passive crosslinking of cytoskeleton scaffolds tune the effects of cell inclusions on composite structure
Katarina Matic, Nimisha Krishnan, Eric Frank +7
Incorporating cells within active biomaterial scaffolds is a promising strategy to develop forefront materials that can autonomously sense, respond, and alter the scaffold in respo…
Kinesin-driven de-mixing of cytoskeleton composites drives emergent mechanical properties
Janet Sheung, Christopher Gunter, Katarina Matic +5
The cytoskeleton is an active composite of filamentous proteins that dictates diverse mechanical properties and processes in eukaryotic cells by generating forces and autonomously…
DNA transport is topologically sculpted by active microtubule dynamics
Dylan P. McCuskey, Raisa E. Achiriloaie, Claire Benjamin +6
The transport of macromolecules, such as DNA, through the cytoskeleton is critical to wide-ranging cellular processes from cytoplasmic streaming to transcription. The rigidity and…
Cooperative rheological state-switching of enzymatically-driven composites of circular DNA and dextran
Juexin Marfai, Ryan J. McGorty, Rae M. Robertson-Anderson
Polymer topology, which plays a principal role in the rheology of polymeric fluids, and non-equilibrium materials, which exhibit time-varying rheological properties, are topics of…
Timed material self-assembly controlled by circadian clock proteins
Gregor Leech, Lauren Melcher, Michelle Chiu +10
Active biological molecules present a powerful, yet largely untapped, opportunity to impart autonomous regulation to materials. Because these systems can function robustly to regul…
Polymer threadings and rigidity dictate the viscoelasticity and nonlinear relaxation dynamics of entangled ring-linear blends and their composites with rigid rod microtubules
Karthik R. Peddireddy, Ryan Clairmont, Rae M. Robertson-Anderson
Mixtures of polymers of varying topologies and stiffnesses display complex emergent rheological properties that often cannot be predicted from their single-component counterparts.…
Motor-driven advection competes with crowding to drive spatiotemporally heterogeneous transport in cytoskeleton composites
Janet Y Sheung, Jonathan Garamella, Stella K Kahl +3
The cytoskeleton -- a composite network of biopolymers, molecular motors, and associated binding proteins -- is a paradigmatic example of active matter. Particle transport through…
OpTiDDM (Optical Tweezers integrating Differential Dynamic Microscopy) maps the spatiotemporal propagation of nonlinear stresses in polymer blends and composites
Karthik R. Peddireddy, Ryan Clairmont, Philip Neill +2
How local stresses propagate through polymeric fluids, and, more generally, how macromolecular dynamics give rise to viscoelasticity are open questions vital to wide-ranging scient…
Monge-Ampère functionals for the curvature tensor of a holomorphic vector bundle
Jean-Pierre Demailly
Let be a holomorphic vector bundle on a projective manifold such that is ample. We introduce three functionals related to Griffiths, Nakano and dual Nakano p…
Motor antagonism dictates emergent dynamics in active double networks tuned by crosslinkers
Ryan J. McGorty, Christopher J. Currie, Jonathan Michel +8
The cytoskeleton relies on diverse populations of motors, filaments, and binding proteins acting in concert to enable non-equilibrium processes ranging from mitosis to chemotaxis.…
Sustained Order-Disorder Transitions in a Model Colloidal System Driven by Rhythmic Crosslinking
Lauren Melcher, Elisabeth Rennert, Jennifer Ross +3
Biological systems have the unique ability to self-organize and generate autonomous motion and work. Motivated by this, we investigate a 2D model colloidal network that can repeate…
Topological digestion drives time-varying rheology of entangled DNA fluids
Davide Michieletto, Philip Neill, Simon Weir +4
Understanding and controlling the rheology of polymeric complex fluids that are pushed out-of-equilibrium is a fundamental problem in both industry and biology. For example, to pac…
DNA topology dictates strength and flocculation in DNA-microtubule composites
Karthik R. Peddireddy, Davide Michieletto, Gina Aguirre +3
Polymer composites are ubiquitous in biology and industry alike, owing to their emergent desirable mechanical properties not attainable in single-species systems. At the same time,…
Active restructuring of cytoskeleton composites leads to increased mechanical stiffness, memory, and heterogeneity
Janet Y. Sheung, Daisy H. Achiriloaie, Karthik Peddireddy +5
The composite cytoskeleton, comprising interacting networks of semiflexible actin and rigid microtubules, actively generates forces and restructures using motor proteins such as my…
Active Cytoskeletal Composites Display Emergent Tunable Contractility and Restructuring
Gloria Lee, Gregor Leech, Pancy Lwin +7
The cytoskeleton is a model active matter system that controls diverse cellular processes from division to motility. While both active actomyosin dynamics and actin-microtubule int…
Dynamics and Rheology of Ring-Linear Blend Semidilute Solutions in Extensional Flow: Single Molecule Experiments
Yuecheng Zhou, Charles D. Young, Kathryn E. Regan +7
Ring polymers exhibit unique flow properties due to their closed chain topology. Despite recent progress, we have not yet achieved a full understanding of the nonequilibrium flow b…
Viscoelastic properties of ring-linear DNA blends exhibit non-monotonic dependence on blend composition
K. R. Peddireddy, M. Lee, C. M. Schroeder +1
Entangled ring polymers, along with blends of ring and linear polymers, continue to be a topic of great interest and debate due to the conflicting experimental results in the liter…
Topology-dependent anomalous dynamics of ring and linear DNA are sensitive to cytoskeleton crosslinking
Devynn M. Wulstein, Kathryn E. Regan, Jonathan Garamella +2
Cytoskeletal crowding plays a key role in the diffusion of DNA molecules through the cell, acting as a barrier to effective intracellular transport and conformational stability req…
Unexpected entanglement dynamics in semidilute blends of supercoiled and ring DNA
Karthik R. Peddireddy, Megan Lee, Yuecheng Zhou +4
Blends of polymers of different topologies, such as ring and supercoiled, naturally occur in biology and often exhibit emergent viscoelastic properties coveted in industry. However…
Maximally Stiffening Composites Require Maximally Coupled Rather Than Maximally Entangled Polymer Species
Davide Michieletto, Robert Fitzpatrick, Rae M Robertson-Anderson
Polymer composites are ideal candidates for next generation biomimetic soft materials because of their exquisite bottom-up designability. However, the richness of behaviours comes…