5 papers
Beyond Cox Models: Assessing the Performance of Machine-Learning Methods in Non-Proportional Hazards and Non-Linear Survival Analysis
Ivan Rossi, Flavio Sartori, Cesare Rollo +3
Survival analysis often relies on Cox models, assuming both linearity and proportional hazards (PH). This study evaluates machine and deep learning methods that relax these constra…
Sparsity is All You Need: Rethinking Biological Pathway-Informed Approaches in Deep Learning
Isabella Caranzano, Corrado Pancotti, Cesare Rollo +4
Biologically-informed neural networks typically leverage pathway annotations to enhance performance in biomedical applications. We hypothesized that the benefits of pathway integra…
JanusDDG: A Thermodynamics-Compliant Model for Sequence-Based Protein Stability via Two-Fronts Multi-Head Attention
Guido Barducci, Ivan Rossi, Francesco Codicè +6
Understanding how residue variations affect protein stability is crucial for designing functional proteins and deciphering the molecular mechanisms underlying disease-related mutat…
Mass Balance Approximation of Unfolding Improves Potential-Like Methods for Protein Stability Predictions
Ivan Rossi, Guido Barducci, Tiziana Sanavia +3
The prediction of protein stability changes following single-point mutations plays a pivotal role in computational biology, particularly in areas like drug discovery, enzyme reengi…
SurvHive: a package to consistently access multiple survival-analysis packages
Giovanni Birolo, Ivan Rossi, Flavio Sartori +3
Survival analysis, a foundational tool for modeling time-to-event data, has seen growing integration with machine learning (ML) approaches to handle the complexities of censored da…