94 citations · 96 across the 5 of their papers we have counts for
5 papers
Energetics of Protein-DNA Interactions
Jason E Donald, William W Chen, Eugene I Shakhnovich
Protein-DNA interactions are vital for many processes in living cells, especially transcriptional regulation and DNA modification. To further our understanding of these important p…
All-atom ab initio folding of a diverse set of proteins
Jae Shick Yang, William W. Chen, Jeffrey Skolnick +1
Natural proteins fold to a unique, thermodynamically dominant state. Modeling of the folding process and prediction of the native fold of proteins are two major unsolved problems i…
Information and Protein Interfaces
William W. Chen, Paul J. Choi, Jason E. Donald +1
To confer high specificity and affinity in binding, contacts at interfaces between two interacting macromolecules are expected to exhibit pair preferences for types of atoms or res…
Entropic stabilization of proteins and its proteomic consequences
Igor N. Berezovsky, William W. Chen, Paul J. Choi +1
We report here a new entropic mechanism of protein thermostability due to residual dynamics of rotamer isomerization in native state. All-atom simulations show that Lysines have mu…
An Exact Model of Fluctuations in Gene Expression
William W. Chen, Jeremy L. England, Eugene I. Shakhnovich
Fluctuations in the measured mRNA levels of unperturbed cells under fixed conditions have often been viewed as an impediment to the extraction of information from expression profil…