6 papers
Demographic Distribution Matching between real world and virtual phantom population
Dhrubajyoti Ghosh, Fakrul Islam Tushar, Lavsen Dahal +5
Virtual imaging trials (VITs) offer scalable and cost-effective tools for evaluating imaging systems and protocols. However, their translational impact depends on rigorous comparab…
Virtual Lung Screening Trial (VLST): An In Silico Study Inspired by the National Lung Screening Trial for Lung Cancer Detection
Fakrul Islam Tushar, Liesbeth Vancoillie, Cindy McCabe +16
Clinical imaging trials play a crucial role in advancing medical innovation but are often costly, inefficient, and ethically constrained. Virtual Imaging Trials (VITs) present a so…
Ensemble Survival Analysis for Preclinical Cognitive Decline Prediction in Alzheimer's Disease Using Longitudinal Biomarkers
Dhrubajyoti Ghosh, Samhita Pal, Michael Lutz +1
Predicting the risk of clinical progression from cognitively normal (CN) status to mild cognitive impairment (MCI) or Alzheimer's disease (AD) is critical for early intervention in…
A non-parametric U-statistic testing approach for multi-arm clinical trials with multivariate longitudinal data
Dhrubajyoti Ghosh, Sheng Luo
Randomized clinical trials (RCTs) often involve multiple longitudinal primary outcomes to comprehensively assess treatment efficacy. The Longitudinal Rank-Sum Test (LRST), a robust…
Power and sample size calculation for multivariate longitudinal trials using the longitudinal rank sum test
Dhrubajyoti Ghosh, Xiaoming Xu, Sheng Luo
Neurodegenerative diseases such as Alzheimer's and Parkinson's often exhibit complex, multivariate longitudinal outcomes that require advanced statistical methods to comprehensivel…
A novel longitudinal rank-sum test for multiple primary endpoints in clinical trials: Applications to neurodegenerative disorders
Xiaoming Xu, Dhrubajyoti Ghosh, Sheng Luo
Neurodegenerative disorders such as Alzheimer's disease (AD) present a significant global health challenge, characterized by cognitive decline, functional impairment, and other deb…