77 citations · 369 across the 18 of their papers we have counts for
18 papers
A phase-field model for active contractile surfaces
Sebastian Aland, Claudia Wohlgemuth
The morphogenesis of cells and tissues involves an interplay between chemical signals and active forces on their surrounding surface layers. The complex interaction of hydrodynamic…
A New Hyperelastic Lookup Table for RT-DC
Lucas Daniel Wittwer, Felix Reichel, Paul Müller +2
Real-time deformability cytometry (RT-DC) is an established method that quantifies features like size, shape, and stiffness for whole cell populations on a single-cell level in rea…
On the role of mechanosensitive binding dynamics in the pattern formation of active surfaces
M. Bonati, L. D. Wittwer, S. Aland +1
The actin cortex of an animal cell is a thin polymeric layer attached to the inner side of the plasma membrane. It plays a key role in shape regulation and pattern formation on the…
A computational model of self-organized shape dynamics of active surfaces in fluids
Lucas D. Wittwer, Sebastian Aland
Mechanochemical processes on surfaces such as the cellular cortex or epithelial sheets, play a key role in determining patterns and shape changes of biological systems. To understa…
Stick-Slip Contact Line Motion on Kelvin-Voigt Model Substrates
Dominic Mokbel, Sebastian Aland, Stefan Karpitschka
The capillary traction of a liquid contact line causes highly localized deformations in soft solids, tremendously slowing down wetting and dewetting dynamics by viscoelastic brakin…
Smart mechanically tunable surfaces with shape memory behavior and wetting-programmable topography
Gissela Constante, Indra Apsite, Paul Auerbach +5
This contribution reports for the first time on fabrication and investigation of wetting properties of structured surfaces containing lamellae with an exceptionally high aspect rat…
Is cell segregation like oil and water: asymptotic versus transitory regime
Florian Franke, Sebatian Aland, Hans-Joachim Böhme +2
Segregation of different cell types is a crucial process for the pattern formation in tissues, in particular during embryogenesis. Since the involved cell interactions are complex…
A numerical method for the simulation of viscoelastic fluid surfaces
Eloy de Kinkelder, Leonard Sagis, Sebastian Aland
Viscoelastic surface rheology plays an important role in multiphase systems. A typical example is the actin cortex which surrounds most animal cells. It shows elastic properties fo…
Post-buckling Dynamics of Spherical Shells
Marcel Mokbel, Adel Djellouli, Catherine Quilliet +2
We explore the intrinsic dynamics of spherical shells immersed in a fluid in the vicinity of their buckled state, through experiments and 3D axisymmetric simulations. The results a…
An ALE method for simulations of axisymmetric elastic surfaces in flow
Marcel Mokbel, Sebastian Aland
The dynamics of membranes, shells and capsules in fluid flow has become an active research area in computational physics and computational biology. The small thickness of these ela…
The Poisson ratio of the cellular actin cortex is frequency-dependent
Marcel Mokbel, Kamran Hosseini, Sebastian Aland +1
Cell shape changes are vital for many physiological processes such as cell proliferation, cell migration and morphogenesis. They emerge from an orchestrated interplay of active cel…
A Phase-Field Model for Fluid-Structure-Interaction
Dominic Mokbel, Helmut Abels, Sebastian Aland
In this paper, we develop a novel phase-field model for fluid-structure interaction (FSI), that is capable to handle very large deformations as well as topology changes like contac…
A phase field approach to trabecular bone remodeling
S. Aland, F. Stenger, R. Müller +6
We introduce a continuous modeling approach which combines elastic responds of the trabecular bone structure, the concentration of signaling molecules within the bone and a mechani…
Simulating Organogenesis in COMSOL: Comparison Of Methods For Simulating Branching Morphogenesis
Lucas D. Wittwer, Michael Peters, Sebastian Aland +1
During organogenesis tissue grows and deforms. The growth processes are controlled by diffusible proteins, so-called morphogens. Many different patterning mechanisms have been prop…
Simulating Organogenesis in COMSOL: Phase-Field Based Simulations of Embryonic Lung Branching Morphogenesis
Lucas Daniel Wittwer, Roberto Croce, Sebastian Aland +1
Organogenesis has been studied for decades, but fundamental questions regarding the control of growth and shape remain unsolved. We have recently shown that of all proposed mathema…
Margination of white blood cells - a computational approach by a hydrodynamic phase field model
Wieland Marth, Axel Voigt
We numerically investigate margination of white blood cells and demonstrate the dependency on a number of conditions including hematocrit, the deformability of the cells and the Re…
Diffuse interface models of locally inextensible vesicles in a viscous fluid
Sebastian Aland, Sabine Egerer, John Lowengrub +1
We present a new diffuse interface model for the dynamics of inextensible vesicles in a viscous fluid. A new feature of this work is the implementation of the local inextensibility…
Time integration for diffuse interface models for two-phase flow
Sebastian Aland
We propose a variant of the -scheme for diffuse interface models for two-phase flow, together with three new linearization techniques for the surface tension. These involve eith…