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Large-scale identification of coevolution signals across homo-oligomeric protein interfaces by Direct Coupling Analysis
Guido Uguzzoni, Shalini John Lovis, Francesco Oteri +3
Proteins have evolved to perform diverse cellular functions, from serving as reaction catalysts to coordinating cellular propagation and development. Frequently, proteins do not ex…
Inverse Statistical Physics of Protein Sequences: A Key Issues Review
Simona Cocco, Christoph Feinauer, Matteo Figliuzzi +2
In the course of evolution, proteins undergo important changes in their amino acid sequences, while their three-dimensional folded structure and their biological function remain re…
Context-Aware Prediction of Pathogenicity of Missense Mutations Involved in Human Disease
Christoph Feinauer, Martin Weigt
Amino-acid substitutions are implicated in a wide range of human diseases, many of which are lethal. Distinguishing such mutations from polymorphisms without significant effect on…