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q-bio.QM2010★ 1 cited
Steps and bumps: precision extraction of discrete states of molecular machines using physically-based, high-throughput time series analysis
Max A. Little, Bradley C. Steel, Fan Bai +5
We report new statistical time-series analysis tools providing significant improvements in the rapid, precision extraction of discrete state dynamics from large databases of experi…
q-bio.QM2010
Sparse bayesian step-filtering for high-throughput analysis of molecular machine dynamics
Max A. Little, Nick S. Jones
Nature has evolved many molecular machines such as kinesin, myosin, and the rotary flagellar motor powered by an ion current from the mitochondria. Direct observation of the step-l…