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physics.bio-ph2015★ 21 cited
Dissecting the roles of local packing density and longer-range effects in protein sequence evolution
Amir Shahmoradi, Claus Wilke
What are the structural determinants of protein sequence evolution? A number of site-specific structural characteristics have been proposed, most of which are broadly related to ei…
physics.bio-ph2014
Predicting evolutionary site variability from structure in viral proteins: buriedness, packing, flexibility, and design
Amir Shahmoradi, Dariya K. Sydykova, Stephanie J. Spielman +4
Several recent works have shown that protein structure can predict site-specific evolutionary sequence variation. In particular, sites that are buried and/or have many contacts wit…