2 papers
stat.ME2025
Evaluating virtual-control-augmented trials for reproducing treatment effect from original RCTs
Alex Fernandes, Raphaël Porcher, Viet-Thi Tran +1
This study investigates the use of virtual patient data to augment control arms in randomised controlled trials (RCTs). Using data from the IST and IST3 trials, we simulated RCTs i…
stat.ME2025
Optimal treatment regimes for the net benefit of a treatment
François Petit, Gérard Biau, Raphaël Porcher
We develop a mathematical framework to define an optimal individualized treatment rule (ITR) within the context of prioritized outcomes in a randomized controlled trial. Our optima…