2 citations · 4 across the 10 of their papers we have counts for
4 papers · 1 filter
A web application for the design of multi-arm clinical trials
Michael J Grayling, James MS Wason
Multi-arm designs provide an effective means of evaluating several treatments within the same clinical trial. Given the large number of treatments now available for testing in many…
A review of available software for adaptive clinical trial design
Michael J Grayling, Graham M Wheeler
Background/Aims: The increasing expense of the drug development process has seen interest in the use of adaptive designs (ADs) grow substantially in recent years. Accordingly, much…
Calculations involving the multivariate normal and multivariate t distributions with and without truncation
Michael Grayling, Adrian Mander
This paper presents a set of Stata commands and Mata functions to evaluate different distributional quantities of the multivariate normal distribution, and a particular type of non…
Group Sequential Clinical Trial Designs for Normally Distributed Outcome Variables
Michael Grayling, James Wason, Adrian Mander
In a group sequential clinical trial, accumulated data are analysed at numerous time-points in order to allow early decisions about a hypothesis of interest. These designs have his…