10 papers
Antigen-specific Antibody Multi-modal Foundation Model for Functional Antibody Design
Xiaoliang Shi, Zichen Wang, Runze Ma +2
Antibodies are essential proteins that play a central role in immune recognition by binding specific antigen molecules. Although recent protein language models have enabled progres…
REALM: Retrospective Encoder Alignment for LFP Modeling
Peicheng Wu, Zhenyu Bu, Runze Ma +1
Spike activity has been the dominant neural signal for behavior decoding due to its high spatial and temporal resolution. However, as brain-computer interfaces (BCIs) move toward h…
LiteMedCoT-VL: Parameter-Efficient Adaptation for Medical Visual Question Answering
Runze Ma, Shunbo Jia, Haonan Lyu +2
The reasoning gap between large and compact vision-language models (VLMs) limits the deployment of medical AI on portable clinical devices. Compact VLMs of 2--4B parameters can run…
VCWorld: A Biological World Model for Virtual Cell Simulation
Zhijian Wei, Runze Ma, Zichen Wang +3
Virtual cell modeling aims to predict cellular responses to perturbations. Existing virtual cell models rely heavily on large-scale single-cell datasets, learning explicit mappings…
BEAT-Net: Injecting Biomimetic Spatio-Temporal Priors for Interpretable ECG Classification
Runze Ma, Caizhi Liao
Although deep learning has advanced automated electrocardiogram (ECG) diagnosis, prevalent supervised methods typically treat recordings as undifferentiated one-dimensional (1D) si…
NABench: Large-Scale Benchmarks of Nucleotide Foundation Models for Fitness Prediction
Zhongmin Li, Runze Ma, Jiahao Tan +2
Nucleotide sequence variation can induce significant shifts in functional fitness. Recent nucleotide foundation models promise to predict such fitness effects directly from sequenc…