4 papers
Antigen-specific Antibody Multi-modal Foundation Model for Functional Antibody Design
Xiaoliang Shi, Zichen Wang, Runze Ma +2
Antibodies are essential proteins that play a central role in immune recognition by binding specific antigen molecules. Although recent protein language models have enabled progres…
VCWorld: A Biological World Model for Virtual Cell Simulation
Zhijian Wei, Runze Ma, Zichen Wang +3
Virtual cell modeling aims to predict cellular responses to perturbations. Existing virtual cell models rely heavily on large-scale single-cell datasets, learning explicit mappings…
Retrieval Augmented Diffusion Model for Structure-informed Antibody Design and Optimization
Zichen Wang, Yaokun Ji, Jianing Tian +1
Antibodies are essential proteins responsible for immune responses in organisms, capable of specifically recognizing antigen molecules of pathogens. Recent advances in generative m…
RiboFlow: Conditional De Novo RNA Co-Design via Synergistic Flow Matching
Runze Ma, Zhongyue Zhang, Zichen Wang +4
Ribonucleic acid (RNA) binds to molecules to achieve specific biological functions. While generative models are advancing biomolecule design, existing methods for designing RNA tha…