4 papers
Tissue failure propagation as mediated by circulatory flow
Gurdip Uppal, Gokhan Bahcecioglu, Pinar Zorlutuna +1
Aging is driven by subcellular processes that are relatively well-understood. However the qualitative mechanisms and quantitative dynamics of how these micro-level failures cascade…
Interdependence Theory of Tissue Failure: Bulk and Boundary Effects
Daniel Suma, Aylin Acun, Pinar Zorlutuna +1
The mortality rate of many complex multicellular organisms increase with age, which suggests that net aging damage is accumulative, despite remodeling processes. But how exactly do…
A Tissue Engineered Model of Aging: Interdependence and Cooperative Effects in Failing Tissues
Aylin Acun, Dervis Can Vural, Pinar Zorlutuna
Aging remains a fundamental open problem in modern biology. Although there exist a number of theories on aging on the cellular scale, nearly nothing is known about how microscopic…
Muscle-Cell-Based "Living Diodes"
Uryan Isik Can, Neerajha Nagarajan, Dervis Can Vural +1
A new type of diode that is made entirely of electrically excitable muscle cells and nonexcitable fibroblast cells is designed, fabricated, and characterized. These two cell types…