109 citations · 144 across the 6 of their papers we have counts for
6 papers
Towards Kinetic Modeling of Global Metabolic Networks with Incomplete Experimental Input on Kinetic Parameters
P. Ao, L. W. Lee, Me Lidstrom +2
This is the first report, to our knowledge, on a systematic method for constructing a large scale kinetic metabolic model with incomplete information on kinetic parametersr, and it…
A Generic Rate Equation for modeling Enzymatic Reactions under Living Conditions
L. W. Lee, L. Yin, X. M. Zhu +1
Based on our experience in kinetic modeling of coupled multiple metabolic pathways we propose a generic rate equation for the dynamical modeling of metabolic kinetics. Its symmetri…
Efficiency, Robustness and Stochasticity of Gene Regulatory Networks in Systems Biology: lambda Switch as a Working Example
X. Zhu, L. Yin, L. Hood +2
Phage lambda is one of the most studied biological models in modern molecular biology. Over the past 50 years quantitative experimental knowledge on this biological model has been…
Robustness, Stability and Efficiency of Phage lambda Gene Regulatory Network: Dynamical Structure Analysis
X. -M. Zhu, L. Yin, L. Hood +1
Based on our physical and biological studies we have recently developed a mathematical framework for the analysis of nonlnear dynamics. We call this framework the dynamical structu…
Calculating Biological Behaviors of Epigenetic States in Phage lambda Life Cycle
X. -M. Zhu, L. Yin, L. Hood +1
Gene regulatory network of lambda phage is one the best studied model systems in molecular biology. More 50 years of experimental study has provided a tremendous amount of data at…
Towards the Understanding of Stability Puzzles in Phage lambda
P. Ao, L. Yin
We discuss two aspects, the in vivo and in vitro difference and the modeling of noise, of integrative modeling of network dynamics in biology, using phage lambda as an example. We…