2 papers
quant-ph2025
Co-optimization of codon usage and mRNA secondary structure using quantum computing
Dimitris Alevras, Mihir Metkar, Triet Friedhoff +5
Co-optimizing mRNA sequences for both codon optimality and secondary structure is crucial for producing stable and efficacious mRNA therapeutics. Codon optimization, which adjusts…
quant-ph2025
Towards secondary structure prediction of longer mRNA sequences using a quantum-centric optimization scheme
Vaibhaw Kumar, Dimitris Alevras, Mihir Metkar +9
Accurate prediction of mRNA secondary structure is critical for understanding gene expression, translation efficiency, and advancing mRNA-based therapeutics. However, the combinato…