6 citations · 13 across the 5 of their papers we have counts for
5 papers
Design and Sample Size Determination for Multiple-dose Randomized Phase II Trials for Dose Optimization
Peng Yang, Daniel Li, Ruitao Lin +2
The conventional more-is-better dose selection paradigm, which targets the maximum tolerated dose (MTD), is not suitable for the development of targeted therapies and immunotherapi…
On singular values of large dimensional lag-tau sample autocorrelation matrices
Zhanting Long, Zeng Li, Ruitao Lin
We study the limiting behavior of singular values of a lag- sample auto-correlation matrix of error term in the high-dimensional factor model. We establish the…
TOP: Time-to-Event Bayesian Optimal Phase II Trial Design for Cancer Immunotherapy
Ruitao Lin, Robert L Coleman, Ying Yuan
Immunotherapies have revolutionized cancer treatment. Unlike chemotherapies, immune agents often take longer time to show benefit, and the complex and unique mechanism of action of…
Time-to-Event Model-Assisted Designs to Accelerate Phase I Clinical Trials
Ruitao Lin, Ying Yuan
Two useful strategies to speed up drug development are to increase the patient accrual rate and use novel adaptive designs. Unfortunately, these two strategies often conflict when…
Statistical Properties of the Keyboard Design with Extension to Drug-Combination Trials
Haitao Pan, Ruitao Lin, Ying Yuan
The keyboard design is a novel phase I dose-finding method that is simple and has good operating characteristics. This paper studies theoretical properties of the keyboard design,…