45 citations · 115 across the 13 of their papers we have counts for
4 papers · 1 filter
Modeling generic aspects of ideal fibril formation
Denis Michel
Many different proteins self-aggregate into insoluble fibrils growing apically by reversible addition of elementary building blocks. But beyond this common principle, the modalitie…
Drawing a Waddington landscape to capture dynamic epigenetics
Floriane Nicol-Benoit, Pascale le Goff, Denis Michel
Epigenetics is most often reduced to chromatin marking in the current literature, whereas this notion was initially defined in a more general context. This restricted view ignores…
Conformational selection or induced fit? New insights from old principles
Denis Michel
A long standing debate in biochemistry is to determine whether the conformational changes observed during biomolecular interactions proceed through conformational selection (of pre…
The accuracy of biochemical interactions is ensured by endothermic stepwise kinetics
Denis Michel, Benjamin Boutin, Philippe Ruelle
The discerning behavior of living systems relies on accurate interactions selected from the lot of molecular collisions occurring in the cell. To ensure the reliability of interact…