4 papers
Estimation of separable direct and indirect effects in continuous time
Torben Martinussen, Mats Julius Stensrud
Many research questions involve time-to-event outcomes that can be prevented from occurring due to competing events. In these settings, we must be careful about the causal interpre…
Analysis of time-to-event for observational studies: Guidance to the use of intensity models
Per Kragh Andersen, Maja Pohar Perme, Hans C van Houwelingen +6
This paper provides guidance for researchers with some mathematical background on the conduct of time-to-event analysis in observational studies based on intensity (hazard) models.…
Subtleties in the interpretation of hazard ratios
Torben Martinussen, Stijn Vansteelandt, Per Kragh Andersen
The hazard ratio is one of the most commonly reported measures of treatment effect in randomised trials, yet the source of much misinterpretation. This point was made clear by (Her…
Instrumental variables estimation with competing risk data
Torben Martinussen, Stijn Vansteelandt
Time-to-event analyses are often plagued by both -- possibly unmeasured -- confounding and competing risks. To deal with the former, the use of instrumental variables for effect es…