37 citations · 94 across the 9 of their papers we have counts for
9 papers · 1 filter
Impact of the RNA Binding Domain Localization of the Protein Shell on Virus Particle Stability
Mohammadamin Safdari, Siyu Li, Sanaz Panahandeh +2
The encapsulation of polyanions, whether single-stranded RNAs or synthetic polymers, is primarily driven by attractive electrostatic interactions between the positively charged, st…
Switchable Conformation in Protein Subunits: Unveiling Assembly Dynamics of Icosahedral Viruses
Siyu Li, Guillaume Tresset, Roya Zandi
The packaging of genetic material within a protein shell, called the capsid, marks a pivotal step in the life cycle of numerous single-stranded RNA viruses. Understanding how hundr…
Biophysical Modeling of SARS-CoV-2 Assembly: Genome Condensation and Budding
Siyu Li, Roya Zandi
The COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has spurred unprecedented and concerted worldwide research to curtail and eradicate…
Virus Assembly Pathways inside a Host Cell
Sanaz Panahandeh, Siyu Li, Bogdan Dragnea +1
Simple RNA viruses self-assemble spontaneously and encapsulate their genome into a shell called the capsid. This process is mainly driven by the attractive electrostatic interactio…
Effect of the charge distribution of virus coat proteins on the length of packaged RNAs
Yinan Dong, Siyu Li, Roya Zandi
Single-stranded RNA viruses efficiently encapsulate their genome into a protein shell called the capsid. Electrostatic interactions between the positive charges in the capsid prote…
How a Virus Circumvents Energy Barriers to Form Symmetric Shells
Sanaz Panahandeh, Siyu Li, Laurent Marichal +3
Previous self-assembly experiments on a model icosahedral plant virus have shown that, under physiological conditions, capsid proteins initially bind to the genome through an en ma…