3 papers
math.DS2021
Reflections in excitable media linked to existence and stability of one-dimensional spiral waves
Stephanie Dodson, Timothy J. Lewis
When propagated action potentials in cardiac tissue interact with local heterogeneities, reflected waves can sometimes be induced. These reflected waves have been associated with t…
q-bio.QM2021
Rate-dependent effects of lidocaine on cardiac dynamics: Development and analysis of a low-dimensional drug-channel interaction model
Steffen S. Docken, Colleen E. Clancy, Timothy J. Lewis
State-dependent Na+ channel blockers are often prescribed to treat cardiac arrhythmias, but many Na+ channel blockers are known to have pro-arrhythmic side effects. While the anti…
nlin.AO2018
Synchronization of electrically coupled resonate-and-fire neurons
Thomas Chartrand, Mark S. Goldman, Timothy J. Lewis
Electrical coupling between neurons is broadly present across brain areas and is typically assumed to synchronize network activity. However, intrinsic properties of the coupled cel…