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Heritable Nongenetic Information That is Independent of DNA and That Governs Organismal Development, Tissue Regeneration, and Tumor Architecture
David H Nguyen, Daniel Gallegos
Numerous studies of the tumor microenvironment, interspecies xenografting, and limb regeneration suggest the existence of a Tissue Spatial Code (TSC) that controls tissue structure…
Detecting Partial Rosettes in Tumor Histopathology Using The Cross Product
David H. Nguyen
Tumors of the eye and nervous system often exhibit an arch-like arrangement of nuclei, called rosettes. Pathologists are able to identify rosettes [full circles] and the presence o…
Quantifying Hidden Architectural Patterns in Metaplastic Tumors by Calculating the Quadrant-Slope Index (QSI)
David H. Nguyen
The Quadrant-Slope Index (QSI) method was created in order to detect subtle patterns of organization in tumor images that have metaplastic elements, such as streams of spindle cell…
Quantifying Subtle Regions of Order and Disorder in Tumor Architecture by Calculating the Nearest-Neighbor Angular Profile
David H. Nguyen
Pathologists routinely classify breast tumors according to recurring patterns of nuclear grades, cytoplasmic coloration, and large-scale morphological formations (i.e. streams of s…