5 papers
Numerical predictions of shear stress and cyclic stretch in the healthy pulmonary vasculature
Michelle A. Bartolo, M. Umar Qureshi, Mitchel J. Colebank +2
Isolated post-capillary pulmonary hypertension (Ipc-PH) occurs due to left heart failure, which contributes to 1 out of every 9 deaths in the United States. In some patients, throu…
Structural and hemodynamic properties in murine pulmonary arterial networks under hypoxia-induced pulmonary hypertension
Megan J. Chambers, Mitchel J. Colebank, M Umar Qureshi +2
Detection and monitoring of patients with pulmonary hypertension, defined as mean blood pressure in the main pulmonary artery above 25 mmHg, requires a combination of imaging and h…
Influence of image segmentation on one-dimensional fluid dynamics predictions in the mouse pulmonary arteries
Mitchel J. Colebank, L. Mihaela Paun, M. Umar Qureshi +4
Computational fluid dynamics (CFD) models are emerging as tools for assisting in diagnostic assessment of cardiovascular disease. Recent advances in image segmentation has made sub…
Sensitivity analysis and uncertainty quantification of 1D models of the pulmonary circulation
Mitchel J. Colebank, M. Umar Qureshi, Mette S. Olufsen
This study combines a one-dimensional (1D) model with micro-CT imaging and hemodynamic data to quantify uncertainty of flow and pressure predictions in the pulmonary arteries in a…
MCMC methods for inference in a mathematical model of pulmonary circulation
L. Mihaela Paun, M. Umar Qureshi, Mitchel Colebank +4
This study performs parameter inference in a partial differential equations system of pulmonary circulation. We use a fluid dynamics network model that takes selected parameter val…