2 papers
stat.ME2025
A Comparative Evaluation of Statistical Methods in Hybrid Controlled Trials
Di Ran, Fanni Zhang, Sima Shahsavari +3
Randomized clinical trials (RCTs) are widely considered the gold standard for evaluating the effectiveness of new treatments or interventions in drug development. Still, they may n…
stat.ME2025
CUI-MET: Clinical Utility Index Dose Optimization Approach for Multiple-Dose, Multiple-Outcome Randomized Trial Designs
Fanni Zhang, Kristine Broglio, Michael Sweeting +1
Dose optimization in oncology clinical trials has shifted from seeking the maximum tolerated dose to identifying the Optimal Biological Dose (OBD) that balances therapeutic benefit…