4 papers
A Hybrid Framework for Uncertainty Quantification in Partially Observed Dynamic Biological Systems
Alberto Portela, Julio R. Banga
Mechanistic ordinary differential equation (ODE) models are widely used in systems biology, but uncertainty quantification (UQ) remains difficult when only a subset of state variab…
Generalized Inverse Optimal Control and its Application in Biology
Julio R. Banga, Sebastian Sager
Living organisms exhibit remarkable adaptations across all scales, from molecules to ecosystems. We believe that many of these adaptations correspond to optimal solutions driven by…
Parameter estimation in ODEs: assessing the potential of local and global solvers
M. Fernández de Dios, Ãngel M. González-Rueda, Julio R. Banga +2
We consider the problem of parameter estimation in dynamic systems described by ordinary differential equations. A review of the existing literature emphasizes the need for determi…
Conformal Prediction in Dynamic Biological Systems
Alberto Portela, Julio R. Banga, Marcos Matabuena
Uncertainty quantification (UQ) is the process of systematically determining and characterizing the degree of confidence in computational model predictions. In the context of syste…