3 papers
q-bio.QM2026
A Hybrid Framework for Uncertainty Quantification in Partially Observed Dynamic Biological Systems
Alberto Portela, Julio R. Banga
Mechanistic ordinary differential equation (ODE) models are widely used in systems biology, but uncertainty quantification (UQ) remains difficult when only a subset of state variab…
q-bio.QM2025
Generalized Inverse Optimal Control and its Application in Biology
Julio R. Banga, Sebastian Sager
Living organisms exhibit remarkable adaptations across all scales, from molecules to ecosystems. We believe that many of these adaptations correspond to optimal solutions driven by…
math.OC2025
Parameter estimation in ODEs: assessing the potential of local and global solvers
M. Fernández de Dios, Ãngel M. González-Rueda, Julio R. Banga +2
We consider the problem of parameter estimation in dynamic systems described by ordinary differential equations. A review of the existing literature emphasizes the need for determi…