6 papers
CMT: A Cascade MAR with Topology Predictor for Multimodal Conditional CAD Generation
Jianyu Wu, Yizhou Wang, Xiangyu Yue +5
While accurate and user-friendly Computer-Aided Design (CAD) is crucial for industrial design and manufacturing, existing methods still struggle to achieve this due to their over-s…
Fitness aligned structural modeling enables scalable virtual screening with AuroBind
Zhongyue Zhang, Jiahua Rao, Jie Zhong +22
Most human proteins remain undrugged, over 96% of human proteins remain unexploited by approved therapeutics. While structure-based virtual screening promises to expand the druggab…
UniSTD: Towards Unified Spatio-Temporal Learning across Diverse Disciplines
Chen Tang, Xinzhu Ma, Encheng Su +6
Traditional spatiotemporal models generally rely on task-specific architectures, which limit their generalizability and scalability across diverse tasks due to domain-specific desi…
Revisiting Convolution Architecture in the Realm of DNA Foundation Models
Yu Bo, Weian Mao, Yanjun Shao +6
In recent years, a variety of methods based on Transformer and state space model (SSM) architectures have been proposed, advancing foundational DNA language models. However, there…
Model Decides How to Tokenize: Adaptive DNA Sequence Tokenization with MxDNA
Lifeng Qiao, Peng Ye, Yuchen Ren +5
Foundation models have made significant strides in understanding the genomic language of DNA sequences. However, previous models typically adopt the tokenization methods designed f…
COMET: Benchmark for Comprehensive Biological Multi-omics Evaluation Tasks and Language Models
Yuchen Ren, Wenwei Han, Qianyuan Zhang +13
As key elements within the central dogma, DNA, RNA, and proteins play crucial roles in maintaining life by guaranteeing accurate genetic expression and implementation. Although res…