207 citations · 348 across the 11 of their papers we have counts for
11 papers
Constraining the Time Interval for the Origin of Life on Earth
Ben K. D. Pearce, Andrew S. Tupper, Ralph E. Pudritz +1
Estimates of the time at which life arose on Earth make use of two types of evidence. First, astrophysical and geophysical studies provide a timescale for the formation of Earth an…
A thermodynamic basis for prebiotic amino acid synthesis and the nature of the first genetic code
Paul G. Higgs, Ralph E. Pudritz
Of the twenty amino acids used in proteins, ten were formed in Miller's atmospheric discharge experiments. The two other major proposed sources of prebiotic amino acid synthesis in…
The Mechanisms of Codon Reassignments in Mitochondrial Genetic Codes
Supratim Sengupta, Xiaoguang Yang, Paul G. Higgs
Many cases of non-standard genetic codes are known in mitochondrial genomes. We carry out analysis of phylogeny and codon usage of organisms for which the complete mitochondrial ge…
The response of amino acid frequencies to directional mutation pressure in mitochondrial genome sequences is related to the physical properties of the amino acids and to the structure of the genetic code
Daniel Urbina, Bin Tang, Paul G. Higgs
The frequencies of A, C, G and T in mitochondrial DNA vary among species due to unequal rates of mutation between the bases. The frequencies of bases at four-fold degenerate sites…
A Unified Model of Codon Reassignment in Alternative Genetic Codes
Supratim Sengupta, Paul G. Higgs
Many modified genetic codes are found in specific genomes in which one or more codons have been reassigned to a different amino acid from that in the canonical code. We present a m…
RNA-based Phylogenetic Methods: Application to Mammalian Mitochondrial RNA Sequences
Cendrine Hudelot, Vivek Gowri-Shankar, Howsun Jow +2
The PHASE software package allows phylogenetic tree construction with a number of evolutionary models designed specifically for use with RNA sequences that have conserved secondary…