62 citations · 62 across the 3 of their papers we have counts for
3 papers
A first-principles model of early evolution: Emergence of gene families, species and preferred protein folds
Konstantin Zeldovich, Peiqiu Chen, Boris Shakhnovich +1
In this work we develop a microscopic physical model of early evolution, where phenotype,organism life expectancy, is directly related to genotype, the stability of its proteins in…
Structural similarity enhances interaction propensity of proteins
D. B. Lukatsky, B. E. Shakhnovich, J. Mintseris +1
We study statistical properties of interacting protein-like surfaces and predict two strong, related effects: (i) statistically enhanced self-attraction of proteins; (ii) statistic…
Protein Structure and Evolutionary History Determine Sequence Space Topology
Boris Shakhnovich, Eric Deeds, Charles Delisi +1
Understanding the observed variability in the number of homologs of a gene is a very important, unsolved problem that has broad implications for research into co-evolution of struc…