3 papers
q-bio.BM2025
Probing the Dark Energy in the Functional Protein Universe
Ezequiel A. Galpern, Carlos Bueno, Ignacio E. Sánchez +2
We show how to localize and quantify the functional evolutionary constraints on natural proteins. The method compares the perturbations caused by local sequence variants to the ene…
q-bio.BM2025
Inferring protein folding mechanisms from natural sequence diversity
Ezequiel A. Galpern, Ernesto A. Roman, Diego U. Ferreiro
Protein sequences serve as a natural record of the evolutionary constraints that shape their functional structures. We show that it is possible to use only sequence information to…
q-bio.BM2025
Predicting protein folding dynamics using sequence information
Ezequiel A. Galpern, Federico Caamaño, Diego U. Ferreiro
Natural protein sequences somehow encode the structural forms that these molecules adopt. Recent developments in structure-prediction are agnostic to the mechanisms by which protei…