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q-bio.BM2007
Allosteric communication in Dihydrofolate Reductase: Signaling network and pathways for closed to occluded transition and back
Jie Chen, Ruxandra I. Dima, D. Thirumalai
E. Coli. dihydrofolate reductase (DHFR) undergoes conformational transitions between the closed (CS) and occluded (OS) states which, respectively, describe whether the active site…
q-bio.BM2004
Proteins associated with diseases show enhanced sequence correlation between charged residues
Ruxandra I. Dima, D. Thirumalai
Function of proteins or a network of interacting proteins often involves communication between residues that are well separated in sequence. The classic example is the participatio…
q-bio.BM2003
Asymmetry in the shapes of folded and denatured states of proteins
Ruxandra I. Dima, D. Thirumalai
The asymmetry in the shapes of folded and unfolded states are probed using two parameters, one being a measure of the sphericity and the other that describes the shape. For the fol…