2 papers
q-bio.QM2025
Generation of structure-guided pMHC-I libraries using Diffusion Models
Sergio Mares, Ariel Espinoza Weinberger, Nilah M. Ioannidis
Personalized vaccines and T-cell immunotherapies depend critically on identifying peptide-MHC class I (pMHC-I) interactions capable of eliciting potent immune responses. However, c…
q-bio.QM2025
Continued domain-specific pre-training of protein language models for pMHC-I binding prediction
Sergio E. Mares, Ariel Espinoza Weinberger, Nilah M. Ioannidis
Predicting peptide--major histocompatibility complex I (pMHC-I) binding affinity remains challenging due to extreme allelic diversity (30,000 HLA alleles), severe data scarci…