3 papers
q-bio.QM2025
Stochastic modelling reveals that chromatin folding buffers epigenetic landscapes against sirtuin depletion during DNA damage
Daria Stepanova, Helen M. Byrne, Tomás Alarcón
Epigenetic landscapes, represented by patterns of chemical modifications on histone tails, are essential for maintaining cell identity and tissue homeostasis. These landscapes are…
q-bio.QM2024
Hybrid methods in reaction-diffusion equations
Tomás Alarcón, Natalia Briñas-Pascual, Juan Calvo +2
Simulation of stochastic spatially-extended systems is a challenging problem. The fundamental quantities in these models are individual entities such as molecules, cells, or animal…
q-bio.QM2024
Understanding how chromatin folding and enzyme competition affect rugged epigenetic landscapes
Daria Stepanova, Meritxell Brunet Guasch, Helen M. Byrne +1
Epigenetics plays a key role in cellular differentiation and maintaining cell identity, enabling cells to regulate their genetic activity without altering the DNA sequence. Epigene…