4 papers
Liquid-liquid phase separation enables highly selective viral genome packaging
Layne B. Frechette, Michael F. Hagan
In many viruses, hundreds of proteins assemble an outer shell (capsid) around the viral nucleic acid to form an infectious virion. How the assembly process selects the viral genome…
Emergence of Anti-chemotactic Flocking in Active Biomimetic Colloids
Joseph D. Lopes, Benjamin Winterstrain, Fernando Caballero +11
Competition for resources is a fundamental constraint that guides the self-organization of natural, biological, and human systems, ranging from urban planning and ecosystem develop…
Computer simulations show that liquid-liquid phase separation enhances self-assembly
Layne B. Frechette, Naren Sundararajan, Fernando Caballero +2
Biomolecular condensates are liquid- or gel-like droplets of proteins and nucleic acids formed at least in part through liquid-liquid phase separation. Condensates enable diverse f…
Markov State Model Approach to Simulate Self-Assembly
Anthony Trubiano, Michael F. Hagan
Computational modeling of assembly is challenging for many systems because their timescales vastly exceed those accessible to simulations. This article describes the MultiMSM, whic…