75 citations · 99 across the 5 of their papers we have counts for
5 papers
Ligand-receptor binding kinetics in surface plasmon resonance cells: A Monte Carlo analysis
Jacob Carroll, Matthew Raum, Kimberly Forsten-Williams +1
Surface plasmon resonance (SPR) chips are widely used to measure association and dissociation rates for the binding kinetics between two species of chemicals, e.g., cell receptors…
Self-consistent theory of reversible ligand binding to a spherical cell
Shivam Ghosh, Manoj Gopalakrishnan, Kimberly Forsten-Williams
In this article, we study the kinetics of reversible ligand binding to receptors on a spherical cell surface using a self-consistent stochastic theory. Binding, dissociation, diffu…
Effects of receptor clustering on ligand dissociation: Theory and simulations
Manoj Gopalakrishnan, Kimberly Forsten-Williams, Matthew A. Nugent +1
Receptor-ligand binding is a critical first step in signal transduction and the duration of the interaction can impact signal generation. In mammalian cells, clustering of receptor…
Ligand Rebinding: Self-consistent Mean-field Theory and Numerical Simulations Applied to SPR Studies
Manoj Gopalakrishnan, Kimberly Forsten-Williams, Theressa R. Cassino +3
Rebinding of dissociated ligands from cell surface proteins can confound quantitative measurements of dissociation rates important for characterizing the affinity of binding intera…
Ligand-induced Coupling versus Receptor Pre-association: Cellular automaton simulations of FGF-2 binding
Manoj Gopalakrishnan, Kimberly Forsten-Williams, Uwe C. Tauber
The binding of basic fibroblast growth factor (FGF-2) to its cell surface receptor (CSR) and subsequent signal transduction is known to be enhanced by Heparan Sulfate Proteoglycans…