86 citations · 117 across the 6 of their papers we have counts for
6 papers
Imperfect DNA Repair and the Error Catastrophe
Yisroel Brumer, Emmanuel Tannenbaum, Eugene I. Shakhnovich
In this Letter, we extend the semiconservative quasispecies equations to incorporate imperfect DNA lesion repair. We study the equilibrium behavior of this model in the limit of in…
The Importance of DNA Repair in Tumor Suppression
Yisroel Brumer, Eugene I. Shakhnovich
The transition from a normal to cancerous cell requires a number of highly specific mutations that affect cell cycle regulation, apoptosis, differentiation, and many other cell fun…
Numerical Investigation of the Entropy Crisis in Model Glass Formers
Yisroel Brumer, David R. Reichman
We investigate numerically the low temperature equilibration of glassy systems via non-local Monte Carlo methods. We re-examine several systems that have been studied previously an…
Host-Parasite Co-evolution and Optimal Mutation Rates for Semi-conservative Quasispecies
Yisroel Brumer, Eugene I. Shakhnovich
In this paper, we extend a model of host-parasite co-evolution to incorporate the semi-conservative nature of DNA replication for both the host and the parasite. We find that the o…
A Selective Advantage for Conservative Viruses
Yisroel Brumer, Eugene I. Shakhnovich
In this letter we study the full semi-conservative treatment of a model for the co-evolution of a virus and an adaptive immune system. Regions of viability are calculated for both…
Mean-Field Theory, Mode-Coupling Theory, and the Onset Temperature in Supercooled Liquids
Yisroel Brumer, David R. Reichman
We consider the relationship between the temperature at which averaged energy landscape properties change sharply (), and the breakdown of mean-field treatments of the dynam…