107 citations · 442 across the 10 of their papers we have counts for
10 papers
The infinitesimal model with dominance
N. H. Barton, A. M. Etheridge, A. Véber
The classical infinitesimal model is a simple and robust model for the inheritance of quantitative traits. In this model, a quantitative trait is expressed as the sum of a genetic…
Dynamic maximum entropy provides accurate approximation of structured population dynamics
K. Bodova, E. Szep, N. H. Barton
Realistic models of biological processes typically involve interacting components on multiple scales, driven by changing environment and inherent stochasticity. Such models are oft…
Evolution of new regulatory functions on biophysically realistic fitness landscapes
Tamar Friedlander, Roshan Prizak, Nicholas H. Barton +1
Regulatory networks consist of interacting molecules with a high degree of mutual chemical specificity. How can these molecules evolve when their function depends on maintenance of…
A general approximation for the dynamics of quantitative traits
Katarína Boďová, Gašper Tkačik, Nicholas H. Barton
Selection, mutation and random drift affect the dynamics of allele frequencies and consequently of quantitative traits. While the macroscopic dynamics of quantitative traits can be…
Intrinsic limits to gene regulation by global crosstalk
Tamar Friedlander, Roshan Prizak, Călin C. Guet +2
Gene regulation relies on the specificity of transcription factor (TF) - DNA interactions. In equilibrium, limited specificity may lead to crosstalk: a regulatory state in which a…
Dynamics of transcription factor binding site evolution
Murat Tuğrul, Tiago Paixão, Nicholas H. Barton +1
Evolution of gene regulation is crucial for our understanding of the phenotypic differences between species, populations and individuals. Sequence-specific binding of transcription…