7 papers
A quantum computing approach to beam angle optimization
Nimita Shinde, Ya-Nan Zhu, Haozheng Shen +1
Background: Beam angle optimization (BAO) is a critical component of radiation therapy (RT) treatment planning, where small changes in beam configuration can significantly impact t…
A fully flexible joint lattice position and dose optimization method for LATTICE therapy
Xin Tong, Weijie Zhang, Ya-Nan Zhu +5
Lattice radiotherapy (LATTICE) is a form of spatially fractionated radiation therapy (SFRT) designed to deliver high doses to tumor regions while sparing surrounding tissues. Tradi…
A Proton Treatment Planning Method for Combining FLASH and Spatially Fractionated Radiation Therapy to Enhance Normal Tissue Protection
Weijie Zhang, Xue Hong, Ya-Nan Zhu +4
Background: FLASH radiation therapy (FLASH-RT) uses ultra-high dose rates to induce the FLASH effect, enhancing normal tissue sparing. In proton Bragg peak FLASH-RT, this effect is…
Joint Range-modulator and Spot Optimization for Bragg-peak Proton FLASH Radiotherapy
Jiayue Han, Ya-Nan Zhu, Aoxiang Wang +3
Background: Ultra-high-dose-rate (UHDR) radiation therapy has demonstrated promising potential in reducing toxicity to organs-at-risk (OARs). Proton therapy is uniquely positioned…
An energy optimization method based on mixed-integer model and variational quantum computing algorithm for faster IMPT
Ya-Nan Zhu, Nimita Shinde, Bowen Lin +1
Intensity-modulated proton therapy (IMPT) offers superior dose conformity with reduced exposure to surrounding healthy tissues compared to conventional photon therapy. Improving IM…
Development and experimental validation of an in-house treatment planning system with greedy energy layer optimization for fast IMPT
Aoxiang Wang, Ya-Nan Zhu, Jufri Setianegara +4
Background: Intensity-modulated proton therapy (IMPT) using pencil beam technique scans tumor in a layer by layer, then spot by spot manner. It can provide highly conformal dose to…