3 papers
physics.med-ph2025
Optimizing normal tissue sparing via spatiotemporal optimization under equivalent tumor-radical efficacy
Nimita Shinde, Wangyao Li, Ronald C Chen +1
Objective: Spatiotemporal optimization in radiation therapy involves determining the optimal number of dose delivery fractions (temporal) and the optimal dose per fraction (spatial…
physics.med-ph2025
A Proton Treatment Planning Method for Combining FLASH and Spatially Fractionated Radiation Therapy to Enhance Normal Tissue Protection
Weijie Zhang, Xue Hong, Ya-Nan Zhu +4
Background: FLASH radiation therapy (FLASH-RT) uses ultra-high dose rates to induce the FLASH effect, enhancing normal tissue sparing. In proton Bragg peak FLASH-RT, this effect is…
physics.med-ph2024
Multi-IMPT: a biologically equivalent approach to proton ARC therapy
Nimita Shinde, Yanan Zhu, Wei Wang +7
Objective: Proton spot-scanning arc therapy (ARC) is an emerging modality that can improve the high-dose conformity to targets compared with standard intensity-modulated proton the…