3 papers
physics.med-ph2025
Optimizing normal tissue sparing via spatiotemporal optimization under equivalent tumor-radical efficacy
Nimita Shinde, Wangyao Li, Ronald C Chen +1
Objective: Spatiotemporal optimization in radiation therapy involves determining the optimal number of dose delivery fractions (temporal) and the optimal dose per fraction (spatial…
physics.med-ph2025
Joint Range-modulator and Spot Optimization for Bragg-peak Proton FLASH Radiotherapy
Jiayue Han, Ya-Nan Zhu, Aoxiang Wang +3
Background: Ultra-high-dose-rate (UHDR) radiation therapy has demonstrated promising potential in reducing toxicity to organs-at-risk (OARs). Proton therapy is uniquely positioned…
physics.med-ph2024
Multi-IMPT: a biologically equivalent approach to proton ARC therapy
Nimita Shinde, Yanan Zhu, Wei Wang +7
Objective: Proton spot-scanning arc therapy (ARC) is an emerging modality that can improve the high-dose conformity to targets compared with standard intensity-modulated proton the…