6 papers
Optimizing normal tissue sparing via spatiotemporal optimization under equivalent tumor-radical efficacy
Nimita Shinde, Wangyao Li, Ronald C Chen +1
Objective: Spatiotemporal optimization in radiation therapy involves determining the optimal number of dose delivery fractions (temporal) and the optimal dose per fraction (spatial…
Minibeam-pLATTICE: A novel proton LATTICE modality using minibeams
Nimita Shinde, Weijie Zhang, Yuting Lin +1
Purpose: LATTICE, a form of spatially fractionated radiation therapy that delivers high-dose peaks and low-dose valleys within the target, has been clinically utilized for treating…
Joint Range-modulator and Spot Optimization for Bragg-peak Proton FLASH Radiotherapy
Jiayue Han, Ya-Nan Zhu, Aoxiang Wang +3
Background: Ultra-high-dose-rate (UHDR) radiation therapy has demonstrated promising potential in reducing toxicity to organs-at-risk (OARs). Proton therapy is uniquely positioned…
A mixed integer programming approach to minibeam aperture optimization for multi-collimator proton minibeam radiotherapy
Nimita Shinde, Weijie Zhang, Yuting Lin +1
Background: Multi-collimator proton minibeam radiation therapy (MC-pMBRT) has recently emerged as a versatile technique for dose shaping, enabling peak-valley dose patterns in orga…
Development and experimental validation of an in-house treatment planning system with greedy energy layer optimization for fast IMPT
Aoxiang Wang, Ya-Nan Zhu, Jufri Setianegara +4
Background: Intensity-modulated proton therapy (IMPT) using pencil beam technique scans tumor in a layer by layer, then spot by spot manner. It can provide highly conformal dose to…
Multi-IMPT: a biologically equivalent approach to proton ARC therapy
Nimita Shinde, Yanan Zhu, Wei Wang +7
Objective: Proton spot-scanning arc therapy (ARC) is an emerging modality that can improve the high-dose conformity to targets compared with standard intensity-modulated proton the…