7 papers
Minibeam-pLATTICE: A novel proton LATTICE modality using minibeams
Nimita Shinde, Weijie Zhang, Yuting Lin +1
Purpose: LATTICE, a form of spatially fractionated radiation therapy that delivers high-dose peaks and low-dose valleys within the target, has been clinically utilized for treating…
A fully flexible joint lattice position and dose optimization method for LATTICE therapy
Xin Tong, Weijie Zhang, Ya-Nan Zhu +5
Lattice radiotherapy (LATTICE) is a form of spatially fractionated radiation therapy (SFRT) designed to deliver high doses to tumor regions while sparing surrounding tissues. Tradi…
A Proton Treatment Planning Method for Combining FLASH and Spatially Fractionated Radiation Therapy to Enhance Normal Tissue Protection
Weijie Zhang, Xue Hong, Ya-Nan Zhu +4
Background: FLASH radiation therapy (FLASH-RT) uses ultra-high dose rates to induce the FLASH effect, enhancing normal tissue sparing. In proton Bragg peak FLASH-RT, this effect is…
Joint Range-modulator and Spot Optimization for Bragg-peak Proton FLASH Radiotherapy
Jiayue Han, Ya-Nan Zhu, Aoxiang Wang +3
Background: Ultra-high-dose-rate (UHDR) radiation therapy has demonstrated promising potential in reducing toxicity to organs-at-risk (OARs). Proton therapy is uniquely positioned…
A mixed integer programming approach to minibeam aperture optimization for multi-collimator proton minibeam radiotherapy
Nimita Shinde, Weijie Zhang, Yuting Lin +1
Background: Multi-collimator proton minibeam radiation therapy (MC-pMBRT) has recently emerged as a versatile technique for dose shaping, enabling peak-valley dose patterns in orga…
Development and experimental validation of an in-house treatment planning system with greedy energy layer optimization for fast IMPT
Aoxiang Wang, Ya-Nan Zhu, Jufri Setianegara +4
Background: Intensity-modulated proton therapy (IMPT) using pencil beam technique scans tumor in a layer by layer, then spot by spot manner. It can provide highly conformal dose to…