2 papers
stat.ME2025
LORDs: Locally Optimal Restricted Designs for Phase I/II Dose-Finding Studies
Oleksandr Sverdlov, Yevgen Ryeznik, Weng Kee Wong
We propose Locally Optimal Restricted Designs (LORDs) for phase I/II dose-finding studies that focus on both efficacy and toxicity outcomes. As an illustrative application, we find…
stat.ME2025
Estimands for Randomized Discontinuation Designs in Oncology
Ayon Mukherjee, Oleksandr Sverdlov, Ngoc-Thuy Ha +1
Randomized discontinuation design (RDD) is an enrichment strategy commonly used to address limitations of traditional placebo-controlled trials, particularly the ethical concern of…