3 papers
cond-mat.stat-mech2026
Optimal feedback control under stepwise equilibration and partial observation
Francesco Mottes, Michael P. Brenner
Many microscopic machines rely on noisy signals to direct nonequilibrium transformations and operate in a timescale-separated regime. We consider feedback protocols in which a syst…
physics.comp-ph2026
Gradient-based optimization of exact stochastic kinetic models
Francesco Mottes, Qian-Ze Zhu, Michael P. Brenner
Stochastic kinetic models describe systems across biology, chemistry, and physics where discrete events and small populations render deterministic approximations inadequate. Parame…
q-bio.CB2025
Engineering morphogenesis of cell clusters with differentiable programming
Ramya Deshpande, Francesco Mottes, Ariana-Dalia Vlad +2
Understanding the rules underlying organismal development is a major unsolved problem in biology. Each cell in a developing organism responds to signals in its local environment by…