5 papers
A Logic-based Temporal Cohort Discovery Engine: Algorithms, Indices, and Experimental Results on the National Sleep Research Resource
Yan Huang, Xiaojin Li, Licong Cui +1
Large sleep-study repositories contain rich time-stamped physiological annotations, but cohort discovery is still commonly implemented as ad hoc scripts or scalar-index filters. We…
Ensemble Logic for Symbolic Representation of Sleep Medicine Guidelines
Jiahao Fan, Xiaojin Li, Yan Huang +3
The American Academy of Sleep Medicine (AASM) Manual is the clinical standard for polysomnography (PSG) scoring, but its narrative rules can admit multiple reasonable interpretatio…
Scaling Up Formal Representation of Clinical Trial Protocols in Ensemble Logic Using LLMs: A Preliminary Study
Yan Huang, Xubing Hao, Xiaojin Li +4
The reliance on unstructured free text for documenting clinical trial protocols creates a significant barrier to automated reasoning, cohort discovery, and trial simulation. The la…
Digital Twins Need Feedback
Guo-Qiang Zhang
Digital twins are too often described as realistic simulations, anatomical avatars, dashboards, or data mirrors. Those artifacts can be useful, but they miss the defining property…
AD-CDO: A Lightweight Ontology for Representing Eligibility Criteria in Alzheimer's Disease Clinical Trials
Zenan Sun, Rashmie Abeysinghe, Xiaojin Li +5
Objective This study introduces the Alzheimer's Disease Common Data Element Ontology for Clinical Trials (AD-CDO), a lightweight, semantically enriched ontology designed to represe…