4 papers
Model-robust standardization in cluster-randomized trials
Fan Li, Jiaqi Tong, Xi Fang +3
In cluster-randomized trials, generalized linear mixed models and generalized estimating equations have conventionally been the default analytic methods for estimating the average…
Semiparametric principal stratification analysis beyond monotonicity
Jiaqi Tong, Brennan Kahan, Michael O. Harhay +1
Intercurrent events, common in clinical trials and observational studies, affect the existence or interpretation of final outcomes. Principal stratification addresses this challeng…
When do composite estimands answer non-causal questions?
Brennan C Kahan, Tra My Pham, Conor Tweed +1
Under a composite estimand strategy, the occurrence of the intercurrent event is incorporated into the endpoint definition, for instance by assigning a poor outcome value to patien…
What is estimated in cluster randomized crossover trials with informative sizes? -- A survey of estimands and common estimators
Kenneth M. Lee, Andrew B. Forbes, Jessica Kasza +5
In the analysis of cluster randomized trials (CRTs), previous work has defined two meaningful estimands: the individual-average treatment effect (iATE) and cluster-average treatmen…