3 papers
stat.AP2025
Evaluating Bias Reduction Methods in Binary Emax Model for Reliable Dose-Response Estimation
Jiangshan Zhang, Vivek Pradhan, Yuxi Zhao
The Binary Emax model is widely employed in dose-response analysis during Phase II clinical studies to identify the optimal dose for subsequence confirmatory trials. The parameter…
stat.ME2025
Cumulative Logit Ordinal Regression with Proportional Odds under Nonignorable Missing Response -- Application to Phase III Trial
Arnab Kumar Maity, Huaming Tan, Vivek Pradhan +1
Missing data are inevitable in clinical trials, and trials that produce categorical ordinal responses are not exempted from this. Typically, missing values in the data occur due to…
stat.ME2024
Robust Emax Model Fitting: Addressing Nonignorable Missing Binary Outcome in Dose-Response Analysis
Jiangshan Zhang, Vivek Pradhan, Yuxi Zhao
The Binary Emax model is widely employed in dose-response analysis during drug development, where missing data often pose significant challenges. Addressing nonignorable missing bi…