109 citations · 497 across the 28 of their papers we have counts for
28 papers
Modularity Emerges from Action-Functional Constraints in Marine Metabolic Networks: A Biology-Scale Validation of the Network-Weighted Action Principle
Martin G. Frasch
Biological systems operate under simultaneous energetic and informational constraints, yet direct evidence that such constraints shape real metabolic networks is limited. The Netwo…
From Static Repositories to Agentic Knowledge Webs: ResearchTwin and the S-Index for Federated Human-AI Research Discovery
Martin G. Frasch
The exponential growth of scientific literature, datasets, and code repositories has created a discovery bottleneck that impedes knowledge synthesis and reproducibility. Traditiona…
The QIC-Index: A Novel, Data-Centric Metric for Quantifying the Impact of Research Data Sharing
Martin G. Frasch
We introduce the QIC-Index, a novel metric to address the failure of publication-centric metrics to value research data sharing. The QIC-Index quantifies the impact of individual d…
Future of Brain Health: From Developmental Insights to Clinical Translation
Mariela Chertoff, Martin G Frasch, Eduardo T Cánepa +4
This review highlights brain health as a dynamic process shaped by both genetic and environmental influences throughout development. Critical periods provide unique windows of heig…
Brain development dictates energy constraints on neural architecture search: cross-disciplinary insights on optimization strategies
Martin G. Frasch
Present day artificial neural architecture search (NAS) strategies are essentially prediction-error-optimized. That holds true for AI functions in general. From the developmental n…
Vagus nerve manipulation and microglial plasticity in the prenatal brain
Marc Courchesne, Colin Wakefield, Karen Nygard +5
The efferent and afferent effects of the vagus nerve on the developing brain have remained enigmatic. Here we review the evidence of such effects on microglial plasticity in the sh…
The vagus nerve regulates immunometabolic homeostasis in the ovine fetus near term: impact on terminal ileum
Mingju Cao, Shikha Kuthiala, Keven Jason Jean +8
The contribution of the vagus nerve to inflammation and glucosensing in the fetus is not understood. We hypothesized that vagotomy (Vx) will trigger a rise in systemic glucose leve…
The role of the vagus nerve during fetal development and its relationship with the environment
Francesco Cerritelli, Martin G. Frasch, Marta C. Antonelli +4
The autonomic nervous system (ANS) regulatory capacity begins before birth as the sympathetic and parasympathetic activity contributes significantly to the fetus' development. Seve…
Prenatal stress perturbs fetal iron homeostasis in a sex-specific manner
Peter Zimmermann, Marta C. Antonelli, Ritika Sharma +7
What is the influence of chronic maternal prenatal stress (PS) on fetal iron homeostasis? In a prospective case-control study in 164 pregnant women, we show that cord blood transfe…
Distance to healthy cardiovascular dynamics from fetal heart rate scale-dependent features in pregnant sheep model of human labor predicts cardiovascular decompensation
Stéphane G. Roux, Nicolas B. Garnier, Patrice Abry +2
The overarching goal of the present work is to contribute to the understanding of the relations between fetal heart rate (FHR) temporal dynamics and the well-being of the fetus, no…
Recording and manipulation of vagus nerve electrical activity in chronically instrumented unanesthetized near term fetal sheep
Aude Castel, Patrick M. Burns, Javier Benito +9
Background: The chronically instrumented pregnant sheep has been used as a model of human fetal development and responses to pathophysiologic stimuli. This is due to the unique ame…
Monitoring fetal electroencephalogram intrapartum: a systematic literature review
Aude Castel, Yael Frank, John Feltner +3
Background: Studies about the feasibility of monitoring fetal electroencephalogram (fEEG) during labor began in the early 1940s. By the 1970s, clear diagnostic and prognostic benef…
Early Biomarkers and Intervention Programs for the Infant Exposed to Prenatal Stress
Marta C. Antonelli, Martin G. Frasch, Mercedes Rumi +4
Functional development of affective and reward circuits, cognition and response inhibition later in life exhibits vulnerability periods during gestation and early childhood. Extens…
Impact of chronic fetal hypoxia and inflammation on cardiac pacemaker cell development
Martin G. Frasch, Dino A. Giussani
Chronic fetal hypoxia and infection are examples of adverse conditions during complicated pregnancy, which impact cardiac myogenesis and increase the lifetime risk of heart disease…
Multimodal pathophysiological dataset of gradual cerebral ischemia in a cohort of juvenile pigs
Martin G. Frasch, Bernd Walter, Christophe L. Herry +1
Ischemic brain injuries are frequent and difficult to detect reliably or early. We present the multi-modal data set containing cardiovascular (blood pressure, blood flow, electroca…
Heart rate variability code: Does it exist and can we hack it?
Martin G. Frasch
Heart rate variability (HRV) has been studied for over 50 years, yet an integrative concept is missing on what HRV's mathematical properties represent physiologically. Here I intro…
Fetal cardiovascular decompensation during labor predicted from the individual heart rate: a prospective study in fetal sheep near term and the impact of low sampling rate
Nathan Gold, Christophe L. Herry, Xiaogang Wang +1
We present a novel computerized fetal heart rate intrapartum algorithm for early and individualized prediction of fetal cardiovascular decompensation, a key event in the causal cha…
Autism spectrum disorder: a neuro-immunometabolic hypothesis of the developmental origins
Martin G. Frasch, Byung-Jun Yoon, Dario-Lucas Helbing +3
Fetal neuroinflammation and prenatal stress (PS) may contribute to lifelong neurological disabilities. Astrocytes and microglia, among the brain's non-neuronal glia cell population…
Chronic stress may disrupt covariant fluctuations of vitamin D and cortisol plasma levels in pregnant sheep during the last trimester: a preliminary report
Colin Wakefield, Ben Janoschek, Yael Frank +4
Psychosocial stress during pregnancy is a known contributor to preterm birth, but also has been increasingly appreciated as an in utero insult acting long-term on prenatal and post…
Fetus: the radar of maternal stress, a cohort study
Silvia M. Lobmaier, Alexander Mueller, Camilla Zelgert +10
Objective: We hypothesized that prenatal stress (PS) exerts lasting impact on fetal heart rate (fHR). We sought to validate the presence of such PS signature in fHR by measuring co…
Vagal contributions to fetal heart rate variability: an omics approach
Christophe L. Herry, Patrick Burns, Andre Desrochers +5
Fetal heart rate variability (fHRV) is an important indicator of health and disease, yet its physiological origins, neural contributions in particular, are not well understood. We…
Microglial memory of early life stress and inflammation: susceptibility to neurodegeneration in adulthood
Paula Desplats, Ashley M. Gutierrez, Marta C. Antonelli +1
We review evidence supporting the role of early life programming in the susceptibility for adult neurodegenerative diseases while highlighting questions and proposing avenues for f…
Alpha7 nicotinic acetylcholine receptor signaling modulates ovine fetal brain astrocytes transcriptome in response to endotoxin
M. Cao, J. W. MacDonald, H. L. Liu +12
Neuroinflammation in utero may result in lifelong neurological disabilities. Astrocytes play a pivotal role, but the mechanisms are poorly understood. No early postnatal treatment…
Can a composite heart rate variability biomarker shed new insights about autism spectrum disorder in school-aged children?
Martin G Frasch, Chao Shen, Hau-Tieng Wu +5
High-frequency heart rate variability (HRV) has identified parasympathetic nervous system alterations in autism spectrum disorder (ASD). In a cohort of school-aged children with an…