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physics.bio-ph2020
Label-Free Chemical Nano-Imaging of Intracellular Drug Binding Sites
William S. Hart, Hemmel Amrania, Alice Beckley +7
Optical microscopy has a diffraction limited resolution of about 250 nm. Fluorescence methods (e.g. PALM, STORM, STED) beat this, but they are still limited to 10 s of nm, and the…
physics.bio-ph2018
Mid-infrared Chemical Nano-imaging for Intra-cellular Drug Localisation
William S. Hart, Hemmel Amrania, Alice Beckley +7
In the past two decades a range of fluorescence cell microscopy techniques have been developed which can achieve ~10 nm spatial resolution, i.e. substantially beating the usual lim…