7 citations · 11 across the 6 of their papers we have counts for
7 papers
SumVg: Total heritability explained by all variants in genome-wide association studies based on summary statistics with standard error estimates
Hon-Cheong So, Xiao Xue, Pak-Chung Sham
Genome-wide association studies (GWAS) are commonly employed to study the genetic basis of complex traits and diseases, and a key question is how much heritability could be explain…
A framework to decipher the genetic architecture of combinations of complex diseases: applications in cardiovascular medicine
Liangying Yin, Carlos Kwan-long Chau, Yu-Ping Lin +2
Genome-wide association studies(GWAS) have proven to be highly useful in revealing the genetic basis of complex diseases. At present, most GWAS are studies of a particular single d…
Analysis of genetic differences between psychiatric disorders: Exploring pathways and cell-types/tissues involved and ability to differentiate the disorders by polygenic scores
Shitao Rao, Liangying Yin, Yong Xiang +1
Although displaying genetic correlations, psychiatric disorders are clinically defined as categorical entities as they each have distinguishing clinical features and may involve di…
Turning genome-wide association study findings into opportunities for drug repositioning
Alexandria Lau, Hon-Cheong So
Drug development is a very costly and lengthy process, while repositioned or repurposed drugs could be brought into clinical practice within a shorter time-frame and at a much redu…
A machine learning approach to drug repositioning based on drug expression profiles: Applications to schizophrenia and depression/anxiety disorders
Kai Zhao, Hon-Cheong So
Development of new medications is a very lengthy and costly process. Finding novel indications for existing drugs, or drug repositioning, can serve as a useful strategy to shorten…
Epigenome-wide association study and integrative analysis with the transcriptome based on GWAS summary statistics
Hon-Cheong So
The past decade has seen a rapid growth in omics technologies. Genome-wide association studies (GWAS) have uncovered susceptibility variants for a variety of complex traits. Howeve…